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non selective 5 ht 2 receptor antagonist  (BOC Sciences)


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    BOC Sciences non selective 5 ht 2 receptor antagonist
    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).
    Non Selective 5 Ht 2 Receptor Antagonist, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/non selective 5 ht 2 receptor antagonist/product/BOC Sciences
    Average 93 stars, based on 2 article reviews
    non selective 5 ht 2 receptor antagonist - by Bioz Stars, 2026-03
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    Images

    1) Product Images from "Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling"

    Article Title: Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2022.968976

    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).
    Figure Legend Snippet: Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Techniques Used: Tail Flick Test



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    Image Search Results


    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Journal: Frontiers in Pharmacology

    Article Title: Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling

    doi: 10.3389/fphar.2022.968976

    Figure Lengend Snippet: Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Article Snippet: Methysergide maleate, a non-selective 5-HT 2 receptor antagonist, was obtained from BOC Sciences (5281073; Shirley, NY) while the 5-HT 2A receptor antagonist volinanserin (5311271), the 5-HT 2C antagonist SB-242084 (3644637), the nonselective opioid antagonist naloxone hydrochloride (5464092), the CB 1 inverse agonist rimonabant hydrochloride (104849), and the CB 2 inverse agonist SR144528 (3081355) were all obtained from Cayman Chemical (Ann Arbor, MI).

    Techniques: Tail Flick Test